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Description Zithromax Pills

Generic Zithromax

(Azithromycin)

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Pharmacotherapeutic group

Antibacterial agents. Antibiotics - macrolides.

Composition

Tablets contains 100 mg, 250 mg and 500 mg of azithromycin.

Pharmacodynamics

Azithromycin has an antibacterial (bacteriostatic) action. Azithromycin (buy azithromycin online) which contacts with 50S subunit of ribosomes, inhibits protein biosynthesis, slowing growth and reproduction of bacteria at high concentrations bactericidal effect is possible.

The spectrum of antimicrobial activity of azithromycin is wide, it includes Gram-positive(Streptococcus pneumoniae, Staphylococcus epidermidis, Streptococcus pyogenes, Staphylococcus aureus, Streptococcus C, F, G group, Streptococcus agalctiae, Streptococcus viridans), besides resistant to erythromycin and Gram-negative (Bordetella pertussis, Moraxella catarrhalis ,Haemophilus influenzae, Campylobacter jejuni, Bordetella parapertussis, Legionella pneumophila, Gardnerella vaginalis, Neisseria gonorrhoeae) micro-organisms, anaerobes (Peptostreptococcus spp., Peptococcus, Bacteroides bivius, Clostridium perfringens), mycoplasmas (Mycoplasma pneumoniae), Chlamydia (Chlamydia pneumonia, Chlamydia trachomatis), mycobacteria (mycobacteria avium complex), ureaplasmas (Ureaplasma urealyticum) and spirochetes (Treponema pallidum).

Pharmacokinetics

Resistant to acid, lipophilic. Rapidly absorbed in the gastrointestinal tract. After a single dose of 500 mg the bioavailability makes 37%, the maximum concentration in blood (0.4 mg/l) is achieved in 2-3 hours. Food intake and alcohol consumption reduces the speed and completeness of absorption. In the case of the drug intake soon after eating the maximum concentration in blood (C max) is reduced approximately by 50%. The apparent volume of distribution is 31.1 l/kg and protein binding is inversely proportional to the concentration in blood and makes 7-50%. The half-life T1 / 2 makes 68 hours. The stable level in plasma achieves after 5-7 days.

After it passes easily histohematogenous barriers and comes into tissues. It is also transported by phagocytes, polymorphonuclear leukocytes and macrophages to a place of infection, where is released in the presence of bacteria. It penetrates through the cell membranes (effective for infections caused by intracellular causative agents). The concentrations in tissues and cells is 10-50 times higher than in plasma and in source of infection – by 24-34% higher than in healthy tissues. The high level of concentration in tissues remains within 5-7 days after last injection. In the liver azithromycin (you can buy azithromycin online) demethylates, the formed metabolites are inactive. The plasma clearance - 630 ml/ min. About 50% of the received dose of azithromycin is excreted with bile as unchanged and 6% - with urine. In elderly men (65-85 years old) the pharmacokinetic parameters do not change, in elderly women – C max increases (by 30-50%). In children of 1-5 years old it is decreased in comparison with adults, the maximum concentration in blood, half-life and indicator of AUC.

Indications for use

Azithromycin (buy azithromycin online) help in the following cases. In cases of infections of the upper (bacterial pharyngitis and tonsillitis) and lower (bacterial exacerbation of chronic obstructive pneumonia, interstitial and alveolar pneumonia, bacterial bronchitis) respiratory tract, upper respiratory tract (tonsillitis, otitis media, laryngitis and sinusitis), genitor-urinary system (urethritis and/or cervicitis), skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis), chronic stage of erythema migrans (the initial stage of Lyme disease), gastric disease and duodenum associated with Helicobacter pylori.

Dosage and dosing regimen

Buy azithromycin online and then receive a pill once per day 1 hour before meal or 2 hours after meal. In the first day of treatment adults are given a dose of 0.5 g/day, from the 2d to 5th day - 0.25 g/day. The course dose - 1.5g. In case of urogenital diseases - 1 g single dose, with Lyme disease - 1g in the 1st day, from the 2d to day 5th - 0.5 g (the course dose - 3 g). In case of gastric disease and duodenum, associated with Helicobacter pylori take 1 g/day during 3 days in complex with a combination therapy. Children over 12 months in the first day of therapy - 10 mg/kg body weight once per day, then during 4 days of treatment- 5 mg/ kg/day or 10 mg/kg/day during 3 days (the course dose - 30 mg/kg body weight). In case of Lyme disease – in the first day 20 mg/kg/day, from the 2d to 5th day - 10 mg/kg/day. In the case of missing a dose take the missed dose as soon as possible and the next one - with intervals of 24 hours.

Cautions

For elderly individuals and patients with impaired renal function there is no necessity to change the dosage.

Side effect

Diarrhea, nausea, abdominal pain, constipation, melena, vomiting, flatulence, cholestatic jaundice, chest pain, weakness, palpitations, headache, dizziness, drowsiness, insomnia, conjunctivitis, nephritis, vaginitis, neutropenia or neutrophilia, moderate increase in the reversible liver enzymes, pseudomembranous colitis, candidiasis, photosensitivity, skin rash, angioedema, eosinophilia in children, in addition - hyperkinesia.

Contraindications

Hypersensitivity (including other macrolides), severe liver problems, pregnancy, lactation (during the treatment breastfeeding is suspended).

Precautions

Buy azithromycin online only based on your doctor’s recommendations. With care it is prescribed to people with evident kidneys dysfunction, hepatic dysfunction (especially in children) and cardiac arrhythmias (ventricular arrhythmias and prolongation of QT interval). After ceasing the treatment hypersensitivity reactions in some patients can remain, in this case the specific therapy under medical supervision is necessary.

Interactions with other drugs

Antacids reduce the absorption of azithromycin (you can buy azithromycin online), the recommended break in taking it in is less than 2 hours between doses). Despite the fact that azithromycin is weaker than erythromycin, it inhibits the cytochrome P450, so a careful control over a patient with a single prescription of drugs, metabolized by the liver is required. Azithromycin increases the effects of ergot alkaloids and dihydroergotamine. It slows down the secretion, increases concentration in plasma and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, medicines undergoing microsomal oxidation (carbamazepine, ergot alkaloids, valproic acid, geksobarbital, phenytoin, disopyramide, bromocriptine, theophylline and other xanthine derivatives, oral hypoglycemic drugs). Lincosamides weaken the effectiveness, tetracycline and chloramphenicol - increase. Pharmaceutical incompatible with heparin. It is dangerous to combine azithromycin (you can buy azithromycin online) with drugs that prolong QT interval during ECG.

Overdose

Symptoms: temporary loss of hearing, nausea, vomiting and diarrhea. Treatment: symptomatic (no specific antidote).